反应详情

A solution of 2-(4-{3-[1-(3,4-dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl}-phenoxy)-2-methyl-propionic acid tert-butyl ester (0.051 g, 0.106 mmol) in CH2Cl2 (3 mL) was treated with trifluoroacetic acid (0.5 mL) and stirred at room temperature under N2 for 5 h. The solvent removed in vacuo to give crude acid that was purified by flash chromatography using 94:6 CH2Cl2:MeOH to afford 0.011 g (24%) 2-(4-{3-[1-(3,4-dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl}-phenoxy) -2-methyl-propionic acid. MS (ES+) Calc'd for C25H33N2O4 (M+1) 425. Found m/z 425 (100%). 1H NMR.

1. customThe solvent removed in vacuo
2. customto give crude acid that
3. customwas purified by flash chromatography