反应详情

A mixture of 3-(4-benzyloxy-phenyl)-2-cyclopentyloxy-propionic acid cyclopentyl ester (0.137 g, 0.335 mmol) and 10% Pd/C (0.14 g) in EtOAc (70 mL) was purged with N2 then H2 and then stirred under a H2 balloon atmosphere for 3 h at room temperature. Upon reaction completion, MgSO4 was added and the mixture filtered through hyflo. The solvent was removed in vacuo to afford 0.090 g (84%) 2-cyclopentyloxy-3-(4-hydroxy-phenyl)-propionic acid cyclopentyl ester. 1H NMR. MS (ES−) Calc'd for C19H25O4 (M−1) 317. Found m/z 317 (100%).

1. customwas purged with N2
2. customUpon reaction completion, MgSO4
3. additionwas added
4. filtrationthe mixture filtered through hyflo
5. customThe solvent was removed in vacuo