HCID 10218034, compound → HCID 68867530, compound

HRID 1985272Notes

Reaction equation

HRID 1985272 reaction equation
[CH3:1][O:2][C:3](=[O:38])[C:4]([O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][CH:17]2[CH2:21][N:20]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]([CH3:32])([CH3:31])[CH3:30])=[CH:25][CH:24]=3)[C:19](=[O:33])[N:18]2[CH3:34])=[CH:10][C:9]=1[CH2:35][CH:36]=[CH2:37])([CH3:6])[CH3:5]>C(O)C>[CH3:1][O:2][C:3](=[O:38])[C:4]([O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][CH:17]2[CH2:21][N:20]([CH2:22][C:23]3[CH:24]=[CH:25][C:26]([C:29]([CH3:30])([CH3:31])[CH3:32])=[CH:27][CH:28]=3)[C:19](=[O:33])[N:18]2[CH3:34])=[CH:10][C:9]=1[CH2:35][CH2:36][CH3:37])([CH3:5])[CH3:6]

Participants

3

Reactant 1

HCID 10218034HCID 10218034, compound

Product 1

HCID 68867530HCID 68867530, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(2-Allyl-4-{3-[1-(4-tert-butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-phenoxy)-2-methyl-propionic acid methyl ester (0.060 g, 0.115 mmole) was dissolved in absolute ethanol (10 mL). After purged the solution with N2 for 15 min, 10% Pd/C (0.030 g). The reaction was stirred under a hydrogen balloon at room temperature for 2 hours. The catalyst was removed through filtration, and solvent was removed on rota-vapor to provide a colorless oil (0.053 g, 88%). Mass [EI+] 523 (M+H)+.

Workup

  1. customAfter purged the solution with N2 for 15 min
  2. customThe catalyst was removed through filtration, and solvent
  3. customwas removed on rota-vapor

Sources & evidence

ORD record
ord-6c2bd1e3f5cd46429290d17aed8b1b24
Source dataset
uspto-grants-2009_06
Patent number
US07544812B2

Reaction notes

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