HCID 68869975, compound → HCID 68867342, compound

HRID 1985274Notes

Reaction equation

HRID 1985274 reaction equation
[CH3:1][O:2][C:3](=[O:36])[C:4]([O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][CH:17]2[CH2:21][N:20](CC3C=CC(C(C)(C)C)=CC=3)[C:19](=[O:33])[N:18]2[CH3:34])=[CH:10][C:9]=1[CH3:35])([CH3:6])[CH3:5]>CC(O)=O>[CH3:1][O:2][C:3](=[O:36])[C:4]([CH3:5])([O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][CH:17]2[CH2:21][NH:20][C:19](=[O:33])[N:18]2[CH3:34])=[CH:10][C:9]=1[CH3:35])[CH3:6]

Participants

3

Reactant 1

HCID 68869975HCID 68869975, compound

Product 1

HCID 68867342HCID 68867342, compoundYield 77.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-methyl-phenoxy)-2-methyl-propionic acid methyl ester (0.620 g, 1.25 mmole) was dissolved in 20% HOAc in EtOAC (50 mL). After purged the solution with N2 for 15 min, 10% Pd/C (0.600 g). The reaction was stirred under a hydrogen balloon at room temperature for overnight. The catalyst was removed through filtration, and solvent was removed on rota-vapor to provide a colorless oil (0.337 g, 77%). Mass [EI+] 349 (M+H)+.

Workup

  1. customAfter purged the solution with N2 for 15 min
  2. customThe catalyst was removed through filtration, and solvent
  3. customwas removed on rota-vapor

Sources & evidence

ORD record
ord-c8c5321c438c4029a4020548b1a0d705
Source dataset
uspto-grants-2009_06
Patent number
US07544812B2

Reaction notes

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