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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1985346Generated: October 26, 2026

4-(Trifluoromethyl)phenyl isocyanate → Dimethyl 2-(3-[2-({[4-(trifluoromethyl)-anilino]carbonyl}oxy)ethyl]benzyl}malonate

https://huagongshe.com/reaction/1985346

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)phenyl isocyanateHCID 73768—
ReactantDimethyl 2-[3-(2-hydroxyethyl)benzyl]malonateHCID 22926790—
ProductDimethyl 2-(3-[2-({[4-(trifluoromethyl)-anilino]carbonyl}oxy)ethyl]benzyl}malonateHCID 57719567—

Reaction Steps

Using dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate and α,α,α-trifluoro-p-tolylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07544835B2
Source datasetuspto-grants-2009_06
ORD IDord-64c55bf6822749d48057dd096276913e
Source noteuspto-grants-2009_06