4-(Trifluoromethyl)phenyl isocyanate → Dimethyl 2-(3-[2-({[4-(trifluoromethyl)-anilino]carbonyl}oxy)ethyl]benzyl}malonate

HRID 1985346Notes

Reaction equation

HRID 1985346 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10].[F:20][C:21]([F:32])([F:31])[C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=[O:30])=[CH:24][CH:23]=1>>[F:20][C:21]([F:31])([F:32])[C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([O:1][CH2:2][CH2:3][C:4]2[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=2)[CH2:7][CH:8]([C:9]([O:11][CH3:12])=[O:10])[C:13]([O:15][CH3:16])=[O:14])=[O:30])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 737684-(Trifluoromethyl)phenyl isocyanateHCID 22926790Dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate

Product 1

HCID 57719567Dimethyl 2-(3-[2-({[4-(trifluoromethyl)-anilino]carbonyl}oxy)ethyl]benzyl}malonate

Procedure

Using dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate and α,α,α-trifluoro-p-tolylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record
ord-64c55bf6822749d48057dd096276913e
Source dataset
uspto-grants-2009_06
Patent number
US07544835B2

Reaction notes

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