4-Methylphenyl isocyanate → Dimethyl 2-(3-{2-[(4-toluidinocarbonyl)oxy]ethyl}benzyl)malonate

HRID 1985348Notes

Reaction equation

HRID 1985348 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10].[C:20]1([CH3:29])[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[O:28])=[CH:22][CH:21]=1>>[C:20]1([CH3:29])[CH:25]=[CH:24][C:23]([NH:26][C:27]([O:1][CH2:2][CH2:3][C:4]2[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=2)[CH2:7][CH:8]([C:9]([O:11][CH3:12])=[O:10])[C:13]([O:15][CH3:16])=[O:14])=[O:28])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 693254-Methylphenyl isocyanateHCID 22926790Dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate

Product 1

HCID 57719522Dimethyl 2-(3-{2-[(4-toluidinocarbonyl)oxy]ethyl}benzyl)malonate

Procedure

Using dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate and p-tolylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record
ord-84cda545b5c64426be01ed520ae8f06f
Source dataset
uspto-grants-2009_06
Patent number
US07544835B2

Reaction notes

Loading…