Methyl 3-chloro-2-nitrobenzoate → Benzoic acid, 2-amino-3-chloro-, methyl ester

Iron powder (1.94 g, 34.8 mmol) was added to the solution of methyl 3-chloro-2-nitrobenzoate (2.5 g, 11.6 mmol) in EtOH/HOAc (100 mL/100 mL) at room temperature, and then the suspension was refluxed under N2 for 2 hrs. After cooling down to room temperature, partial of the solvents was removed on rotary vacuum, the resulting residue was partitioned between H2O/EtOAc (200 mL/300 mL). The separated organic phase was washed with aqueous NaOH (1N, 50 mL), brine (50 mL), dried over MgSO4, and concentrated on rotary vacuum to afford the expected product as a tan oil (1.7 g, 79% yield) which became wax type solid standing on bench. The crude product was pure enough to be used in next step without further purification; 1H NMR (400 MHz, CDCl3) δ ppm 3.86 (s, 3H), 6.25 (s, 2H), 6.57 (t, J=7.93 Hz, 1H), 7.39 (dd, J=7.81, 1.51 Hz, 1H), 7.79 (dd, J=8.06, 1.51 Hz, 1H); Mass spec. 185.95 (MH+), Calc. for C8H8ClNO2 185.02.

1. temperaturethe suspension was refluxed under N2 for 2 hrs
2. customwas removed on rotary vacuum
3. customthe resulting residue was partitioned between H2O/EtOAc (200 mL/300 mL)
4. washThe separated organic phase was washed with aqueous NaOH (1N, 50 mL), brine (50 mL)
5. dry with materialdried over MgSO4
6. concentrationconcentrated on rotary vacuum

ORD record

ord-9a641c2448ab401298a7be6c27ac4aa3

Source dataset

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07544680B2