Hydrazine hydrate (1:1) → 3-tert-Butyl-6,6-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridazine

HRID 1985606Notes

Reaction equation

HRID 1985606 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:6][C:5](=O)[C:4](=O)[CH2:3]1.COP([CH2:16][C:17](=O)[C:18]([CH3:21])([CH3:20])[CH3:19])(=O)OC.O.[NH2:24][NH2:25]>>[C:18]([C:17]1[N:25]=[N:24][C:4]2[CH2:3][C:2]([CH3:9])([CH3:1])[CH2:6][C:5]=2[CH:16]=1)([CH3:21])([CH3:20])[CH3:19]

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 142896544,4-Dimethylcyclopentane-1,2-dioneHCID 14302170Dimethyl (3,3-dimethyl-2-oxobutyl)phosphonate

Product 1

HCID 247726633-tert-Butyl-6,6-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridazine

Procedure

white crystalline solid. MS (ESI): 205.0 (MH+). Prepared from 4,4-dimethyl-cyclopentane-1,2-dione, (3,3-dimethyl-2-oxo-butyl)-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-0877e439d05246c6a9d15acc7e31afee
Source dataset
uspto-grants-2009_06
Patent number
US07547697B2

Reaction notes

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