Hydrazine hydrate (1:1) → (1SR,8RS)-5-Cyclopropylmethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2(7),3,5-triene

HRID 1985610Notes

Reaction equation

HRID 1985610 reaction equation
[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=O)[C:2]2=O.COP([CH2:16][C:17](=O)[CH2:18][CH:19]1[CH2:21][CH2:20]1)(=O)OC.O.[NH2:24][NH2:25]>>[CH:19]1([CH2:18][C:17]2[N:24]=[N:25][C:2]3[CH:1]4[CH2:7][CH:4]([C:3]=3[CH:16]=2)[CH2:5][CH2:6]4)[CH2:21][CH2:20]1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 138696Bicyclo(2.2.1)heptane-2,3-dioneHCID 86617460(3-Cyclopropyl-2-oxo-propyl)-phosphonic acid dimethyl ester

Product 1

HCID 69065119(1SR,8RS)-5-Cyclopropylmethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2(7),3,5-triene

Procedure

light brow oil. MS (ESI): 201.1 (MH+). Prepared from bicyclo[2.2.1]heptane-2,3-dione, (3-cyclopropyl-2-oxo-propyl)-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-ad0cde657c9043e991984e52331f89af
Source dataset
uspto-grants-2009_06
Patent number
US07547697B2

Reaction notes

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