反应详情

温度

120 °C

The mixture of 1.7 g of 2-amino-3-cyano-4-hydroxy-6-dimethylaminoquinoline and 3.4 mL of phosphoryl chloride is stirred at 120° C. for 4 hours. The cooled reaction mixture is poured onto 30 g of ice, the pH of the mixture is adjusted to 8 with 10% NaOH solution and the precipitated material is filtered off. After drying 1.5 g of the title compound is obtained, m.p.: 285° C.

1. customThe cooled reaction mixture
2. filtrationthe precipitated material is filtered off
3. dry with materialAfter drying 1.5 g of the title compound
4. customis obtained