HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 4-Quinazolinamine, 2-(4-bromophenyl)-7-chloro-N-phenyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | 2-(4-Bromophenyl)-4,7-dichloroquinazoline | HCID 51358609 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Quinazolinamine, 2-(4-bromophenyl)-7-chloro-N-phenyl- | HCID 11395782 | — |
Reaction Steps
A solution of 2-(4-bromo-phenyl)-4,7-dichloro-quinazoline (0.085 mmol, 30 mg) in 2 ml THF is treated with aniline (0.01 ml, 0.11 mmol). The suspension is heated to 60° and stirred for 18 hrs. The reaction mixture is filtered and the crystals are washed with THF and dried. [2-(4-Bromo-phenyl)-7-chloro-quinazolin-4-yl]-phenyl-amine is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547702B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-d2118d670747414b9e6992c7fcbf1cef |
| Source note | uspto-grants-2009_06 |