Aniline → 4-Quinazolinamine, 2-(4-bromophenyl)-7-chloro-N-phenyl-

HRID 1985702Notes

Reaction equation

HRID 1985702 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](Cl)[C:15]3[C:10](=[CH:11][C:12]([Cl:19])=[CH:13][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C1COCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:15]3[C:10](=[CH:11][C:12]([Cl:19])=[CH:13][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 513586092-(4-Bromophenyl)-4,7-dichloroquinazoline

Product 1

HCID 113957824-Quinazolinamine, 2-(4-bromophenyl)-7-chloro-N-phenyl-

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-(4-bromo-phenyl)-4,7-dichloro-quinazoline (0.085 mmol, 30 mg) in 2 ml THF is treated with aniline (0.01 ml, 0.11 mmol). The suspension is heated to 60° and stirred for 18 hrs. The reaction mixture is filtered and the crystals are washed with THF and dried. [2-(4-Bromo-phenyl)-7-chloro-quinazolin-4-yl]-phenyl-amine is obtained.

Workup

  1. temperatureThe suspension is heated to 60°
  2. filtrationThe reaction mixture is filtered
  3. washthe crystals are washed with THF
  4. customdried

Sources & evidence

ORD record
ord-d2118d670747414b9e6992c7fcbf1cef
Source dataset
uspto-grants-2009_06
Patent number
US07547702B2

Reaction notes

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