Benzylamine → HCID 68863279, compound

HRID 1985703Notes

Reaction equation

HRID 1985703 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](Cl)[C:15]3[C:10](=[CH:11][C:12]([Cl:19])=[CH:13][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.[CH2:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C1COCC1>[CH2:20]([NH:27][C:16]1[C:15]2[C:10](=[CH:11][C:12]([Cl:19])=[CH:13][CH:14]=2)[N:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=2)[N:17]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 513586092-(4-Bromophenyl)-4,7-dichloroquinazoline

Product 1

HCID 68863279HCID 68863279, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-(4-bromo-phenyl)-4,7-dichloro-quinazoline (0.085 mmol, 30 mg) [prepared analogously to example 1] in 2 ml THF is treated with benzylamine (0.174 mmol, 0.019 ml). The mixture is heated at 60° for 6 hrs. After cooling to rt, the reaction mixture is filtered through a tentacle ion exchanger (LiChrolut® SCX: Merck ChromBook, 2nd ed. page 31). Evaporation of the solvent afforded benzyl-[2-(4-bromo-phenyl)-7-chloroquinazolin-4-yl]-amine.

Workup

  1. temperatureThe mixture is heated at 60° for 6 hrs
  2. filtrationthe reaction mixture is filtered through a tentacle ion exchanger (LiChrolut® SCX: Merck ChromBook, 2nd ed. page 31)
  3. customEvaporation of the solvent

Sources & evidence

ORD record
ord-d8a6f28f79aa4d29af97317c128cc476
Source dataset
uspto-grants-2009_06
Patent number
US07547702B2

Reaction notes

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