HCID 69036038, compound → HCID 69037775, compound

HRID 1985735Notes

Reaction equation

HRID 1985735 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C:9]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])([CH2:12][C:13]#[N:14])[CH2:8][CH2:7]1)=[O:5])[CH3:2]>CO.[Ni]>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C:9]([CH2:12][CH2:13][NH2:14])([NH:15][C:16]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:17])[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 69036038HCID 69036038, compound

Product 1

HCID 69037775HCID 69037775, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To a solution of 5 g (16.06 mmol) of 4-tert-butoxycarbonylamino-4-cyanomethyl-piperidine-1-carboxylic acid ethyl ester in 107 ml of methanol was added 4.71 g of Raney Nickel catalyst. The suspension was hydrogenated under 55 psi pressure at room temperature during 3 h.

Sources & evidence

ORD record
ord-4b246b9dccfb49018b089dabb998b34b
Source dataset
uspto-grants-2009_06
Patent number
US07547705B2

Reaction notes

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