2,4-Difluoro-5-nitrobenzoic acid → 5-Amino-2,4-difluorobenzoic acid

HRID 1985748ノート

反応式

HRID 1985748 の反応式
[F:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([N+:12]([O-])=O)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]>C(O)C.[Pd]>[F:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([NH2:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

4

反応物 1

HCID 27828222,4-Difluoro-5-nitrobenzoic acid

生成物 1

HCID 210494315-Amino-2,4-difluorobenzoic acid収率 97.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 2,4-difluoro-5-nitrobenzoic acid (0.998 g, 4.91 mmol) in ethanol (50 mL) was added 10% palladium on charcoal (107 mg) and the mixture was hydrogenated at 30 psi. After 2 h, the mixture was degassed, filtered and the filtrate was concentrated in vacuo to afford 2,4-difluoro-5-aminobenzoic acid (0.83 g, 97%) as tan solid. LC/MS (ESI); (M−H)−=172.

後処理

  1. customthe mixture was degassed
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-6d7dc8888f42467a8c2337b1297aab3c
出典データセット
uspto-grants-2009_06
特許番号
US07547711B2

反応ノート

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