HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide → 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide | HCID 8469273 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide | HCID 22019122 | 95.5% |
Reaction Steps
The mixture of N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide (520 mg, 2 mmol) and Pd/C (10%, 100 mg) in EtOH was hydrogenated (1 atm) overnight. The mixture was filtered through a short pad of celite and concentrated in vacuo to afford N-cyclopropyl-4-fluoro-3-aminobenzenesulfonamide (440 mg, 95% ) as an ivory solid. LC/MS; (M+H)+=231.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547711B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-3bfc2133ea37416486880197115a7097 |
| Source note | uspto-grants-2009_06 |