1,4-Dioxane hydrochloride → HCID 68865577, compound

Participants

Reaction Steps

Methyl 2(R)-tert-butoxycarbonylamino-3-(pyrazin-2-ylmethanesulfonyl)propionate was dissolved in THF (5 mL) and a solution of HCl/dioxane (4.0 M, 2.9 mL) was added. After stirring for 48 h, the solvent was removed in vacuo and the residue was precipitated with diethyl ether and dried under vacuum to give methyl 2(R)-amino-3-(pyrazin-2-ylmethanesulfonyl)propionate which was converted to the title compounds utilizing the procedure described in Example 4 above.

Provenance & Evidence