1,4-Dioxane hydrochloride → HCID 68865577, compound

HRID 1985803Notes

Reaction equation

HRID 1985803 reaction equation
C(OC([NH:8][C@@H:9]([CH2:14][S:15]([CH2:18][C:19]1[CH:24]=[N:23][CH:22]=[CH:21][N:20]=1)(=[O:17])=[O:16])[C:10]([O:12][CH3:13])=[O:11])=O)(C)(C)C.Cl.O1CCOCC1>C1COCC1>[NH2:8][C@@H:9]([CH2:14][S:15]([CH2:18][C:19]1[CH:24]=[N:23][CH:22]=[CH:21][N:20]=1)(=[O:16])=[O:17])[C:10]([O:12][CH3:13])=[O:11]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68863165HCID 68863165, compound

Product 1

HCID 68865577HCID 68865577, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methyl 2(R)-tert-butoxycarbonylamino-3-(pyrazin-2-ylmethanesulfonyl)propionate was dissolved in THF (5 mL) and a solution of HCl/dioxane (4.0 M, 2.9 mL) was added. After stirring for 48 h, the solvent was removed in vacuo and the residue was precipitated with diethyl ether and dried under vacuum to give methyl 2(R)-amino-3-(pyrazin-2-ylmethanesulfonyl)propionate which was converted to the title compounds utilizing the procedure described in Example 4 above.

Workup

  1. customthe solvent was removed in vacuo
  2. customthe residue was precipitated with diethyl ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-67b98815eb9b46cfb3ff1c40f56190a0
Source dataset
uspto-grants-2009_06
Patent number
US07547701B2

Reaction notes

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