HCID 57720285, compound → HCID 57720276, compound

HRID 1985846Notes

Reaction equation

HRID 1985846 reaction equation
C([O:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:15]=[C:16]([CH:37]=[CH:38][CH:39]=1)[CH2:17][NH:18][C:19]1[N:23]([C@@H:24]2[O:30][C@H:29]([CH2:31][OH:32])[C@@H:27]([OH:28])[C@H:25]2[OH:26])[C:22]2[CH:33]=[CH:34][CH:35]=[CH:36][C:21]=2[N:20]=1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[OH:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:15]=[C:16]([CH:37]=[CH:38][CH:39]=1)[CH2:17][NH:18][C:19]1[N:23]([C@@H:24]2[O:30][C@H:29]([CH2:31][OH:32])[C@@H:27]([OH:28])[C@H:25]2[OH:26])[C:22]2[CH:33]=[CH:34][CH:35]=[CH:36][C:21]=2[N:20]=1

Participants

4

Reactant 1

HCID 57720285HCID 57720285, compound

Product 1

HCID 57720276HCID 57720276, compoundYield 100.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

2-[3-(4-Benzyloxybutyloxy)benzylamino]-1-(β-D-ribofuranosyl)-1H-benzimidazole (24 mg) was dissolved in ethanol (2 mL). To the solution was added a catalytic amount of 10% palladium-carbon powder, and the mixture was stirred at 60° C. under a hydrogen atmosphere for 24 hour. The insoluble material was removed by filtration, and the solvent of the filtrate was removed under reduced pressure to give the title compound (20 mg).

Workup

  1. customThe insoluble material was removed by filtration
  2. customthe solvent of the filtrate was removed under reduced pressure

Sources & evidence

ORD record
ord-4ff368cf81f24504b38875f20592fca7
Source dataset
uspto-grants-2009_06
Patent number
US07547680B2

Reaction notes

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