反应详情

To a solution of 2-azido-1-(4-fluoro-phenyl)-ethanone in ethanol is added concentrated HCl (aq) and 10% Pd/C (10 mol %). The mixture is stirred under hydrogen (H2) atmosphere at 45 psi for 1 hour. The mixture is filtered through celite and the celite cake is washed with copious amounts of methanol. The solvent is removed under reduce pressure and the resulting residue is triturated with diethyl ether, filtered and dried to give 2-amino-1-(4-fluoro-phenyl)-ethanone hydrochloride.

1. filtrationThe mixture is filtered through celite
2. washthe celite cake is washed with copious amounts of methanol
3. customThe solvent is removed
4. customthe resulting residue is triturated with diethyl ether
5. filtrationfiltered
6. customdried