Hydrochloric Acid → HCID 57720839, compound

Participants

Reaction Steps

A mixture of 3-(1-(4-chlorophenyl)-5-(4-fluorophenyl)-1,2-dihydro-2-thioxoimidazol-3-yl)propionic acid ethyl ester (1 eq) and lithium hydroxide hydrate (1.2 eq) is dissolved in 1,4-dioxane:water (4/1:v/v) and allowed to stir at room temperature for 3 hours. The reaction mixture is neutralized with aqueous 2N HCl and extracted with ethyl acetate. The organics are dried and concentrated under vacuum to give 3-(1-(4-chlorophenyl)-5-(4-fluorophenyl)-1,2-dihydro-2-thioxoimidazol-3-yl)propionic acid.

Provenance & Evidence