Hydrochloric Acid → HCID 57720839, compound

HRID 1985864Notes

Reaction equation

HRID 1985864 reaction equation
C([O:3][C:4](=[O:27])[CH2:5][CH2:6][N:7]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[N:9]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[C:8]1=[S:26])C.O.[OH-].[Li+].O.Cl>O1CCOCC1>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([N:9]2[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)=[CH:11][N:7]([CH2:6][CH2:5][C:4]([OH:27])=[O:3])[C:8]2=[S:26])=[CH:20][CH:21]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 11395605HCID 11395605, compound

Product 1

HCID 57720839HCID 57720839, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 3-(1-(4-chlorophenyl)-5-(4-fluorophenyl)-1,2-dihydro-2-thioxoimidazol-3-yl)propionic acid ethyl ester (1 eq) and lithium hydroxide hydrate (1.2 eq) is dissolved in 1,4-dioxane:water (4/1:v/v) and allowed to stir at room temperature for 3 hours. The reaction mixture is neutralized with aqueous 2N HCl and extracted with ethyl acetate. The organics are dried and concentrated under vacuum to give 3-(1-(4-chlorophenyl)-5-(4-fluorophenyl)-1,2-dihydro-2-thioxoimidazol-3-yl)propionic acid.

Workup

  1. extractionextracted with ethyl acetate
  2. customThe organics are dried
  3. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-0d9e7d324dff4dd89fe336d1e15d7c8b
Source dataset
uspto-grants-2009_06
Patent number
US07547717B2

Reaction notes

Loading…