Acetic Anhydride → 1-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

HRID 1985871Notes

Reaction equation

HRID 1985871 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([F:1])[CH:10]=2)[CH2:6][C:7]1=[O:11])(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 37310136-fluoro-2,3-dihydro-1H-indol-2-one2×

Product 1

HCID 581603571-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

Procedure

At 130° C., 82.5 g of 6-fluoro-2-indolinone (starting material IV) are stirred in 180 ml acetic anhydride for 3 hours. After cooling to room temperature, the precipitate is filtered off with suction, washed with 100 ml of petroleum ether and dried.

Workup

  1. filtrationthe precipitate is filtered off with suction
  2. washwashed with 100 ml of petroleum ether
  3. customdried

Sources & evidence

ORD record
ord-adc43d01e23a41719a210b5d79cb3cf3
Source dataset
uspto-grants-2009_06
Patent number
US07547703B2

Reaction notes

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