HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 1-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 6-fluoro-2,3-dihydro-1H-indol-2-one | HCID 3731013 | — |
| Product | 1-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one | HCID 58160357 | — |
Reaction Steps
At 130° C., 82.5 g of 6-fluoro-2-indolinone (starting material IV) are stirred in 180 ml acetic anhydride for 3 hours. After cooling to room temperature, the precipitate is filtered off with suction, washed with 100 ml of petroleum ether and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547703B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-adc43d01e23a41719a210b5d79cb3cf3 |
| Source note | uspto-grants-2009_06 |