Hexamethylenetetramine → 3,5-Difluoro-4-hydroxybenzaldehyde

HRID 1985917Notes

Reaction equation

HRID 1985917 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[OH:9].C1N2CN3CN(C2)CN1C3.O.[C:21](O)(=[O:23])C>>[F:1][C:2]1[CH:7]=[C:6]([CH:5]=[C:4]([F:8])[C:3]=1[OH:9])[CH:21]=[O:23]

Participants

4

Reactant 3

HCID 4101HexamethylenetetramineHCID 943922,6-DifluorophenolHCID 21899381Acetic acid--water (1/1)

Product 1

HCID 101925843,5-Difluoro-4-hydroxybenzaldehyde

Procedure

2,6-difluorophenol (1 eq) and hexamethylenetetramine (2 eq) were dissolved in a water/acetic acid mixture (10:90). The reaction mixture was refluxed for 18 hours then cooled to room temperature.

Workup

  1. temperatureThe reaction mixture was refluxed for 18 hours

Sources & evidence

ORD record
ord-b18ec6546f094b1da3c4822f3ddb8a6f
Source dataset
uspto-grants-2009_06
Patent number
US07547729B2

Reaction notes

Loading…