Aluminium lithium hydride → 1-Pentanol, 2-amino-3-ethyl-5,5,5-trifluoro-, (2S,3S)-

Temperature

40 °C

(2S,3S)-2-Azido-3-ethyl-5,5,5-trifluoro-pentanoic acid was dissolved in THF (5 mL) at 0° C. and lithium aluminum hydride (1 M solution in THF) (1 mL, 1 mmol) was added. The resulting solution was stirred at 40° C. for 2 h. The reaction was quenched by sequential addition of water (60 μL), 15% aqueous sodium hydroxide (60 μL), and water (150 μL) with vigorous stirring between each addition. The mixture was then filtered and concentrated to give (2S,3S)-2-amino-3-ethyl-5,5,5-trifluoro-pentan-1-ol.

1. customThe reaction was quenched by sequential addition of water (60 μL), 15% aqueous sodium hydroxide (60 μL), and water (150 μL)
2. stirringwith vigorous stirring between each addition
3. filtrationThe mixture was then filtered
4. concentrationconcentrated

ORD record

ord-75748648b2d44f988b8832c895872ed2

Source dataset

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07547725B2