4,4,4-Trifluoro-2-(2,2,2-trifluoroethyl)but-2-enoic acid ethyl ester → 4,4,4-Trifluoro-2-(2,2,2-trifluoroethyl)-butyric acid ethyl ester

HRID 1985964노트

반응식

HRID 1985964 반응식
[CH2:1]([O:3][C:4](=[O:16])[C:5]([CH2:11][C:12]([F:15])([F:14])[F:13])=[CH:6][C:7]([F:10])([F:9])[F:8])[CH3:2]>C1COCC1.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[CH:5]([CH2:11][C:12]([F:13])([F:14])[F:15])[CH2:6][C:7]([F:8])([F:10])[F:9])[CH3:2]

참가 물질

4

반응물 1

HCID 744100564,4,4-Trifluoro-2-(2,2,2-trifluoroethyl)but-2-enoic acid ethyl ester

생성물 1

HCID 445414254,4,4-Trifluoro-2-(2,2,2-trifluoroethyl)-butyric acid ethyl ester수율 99.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

4,4,4-Trifluoro-2-(2,2,2-trifluoroethyl)-but-2-enoic acid ethyl ester (5.0 g, 20.0 mmol) in THF (20 mL) was treated with Pd/C (2.5 g, 5%), and H2 (1 atm.) at 25° C. for 17 h. The reaction mixture was filtered through a pad of the Celite® reagent, rinsed with Et2O (50 mL) and the filtrate was distilled to remove Et2O and THF to afford the product as colorless liquid (5.0 g, 99%).

후처리

  1. filtrationThe reaction mixture was filtered through a pad of the Celite® reagent
  2. washrinsed with Et2O (50 mL)
  3. distillationthe filtrate was distilled
  4. customto remove Et2O and THF

출처 및 근거

ORD 기록
ord-88c0e1a63db3412d8a3e3a4847a76e0d
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07547725B2

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