反应详情

5.0 g of fludarabine-phosphate at a purity of 96.1% is dissolved in 30 ml of water, and 6.5 ml of a potassium carbonate solution (18.5% by weight) is added to this solution below 30° C. It is stirred for 15 more minutes, then solid material is filtered out. The clear solution that is thus obtained is poured into acetone at 50° C., cooled to room temperature and stirred for 2 more hours. The deposited precipitate is filtered and washed twice with acetone. 4.5 g of fludarabine-phosphate dipotassium salt is obtained.

1. filtrationsolid material is filtered out
2. customThe clear solution that is thus obtained
3. stirringstirred for 2 more hours
4. filtrationThe deposited precipitate is filtered
5. washwashed twice with acetone