Hydrochloric Acid → 5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid--hydrogen chloride (1/1)

HRID 1986039Notes

Reaction equation

HRID 1986039 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2[N:8]=[C:9]([C:11]([O-:13])=[O:12])[S:10][C:4]=2[CH2:3]1.[Li+].[ClH:15]>C(O)C>[ClH:15].[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2[N:8]=[C:9]([C:11]([OH:13])=[O:12])[S:10][C:4]=2[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate

Product 1

HCID 111490315-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate (3.00 g) was added 1N HCl in ethanol (36 mL), and the mixture was stirred at room temperature for 1 hour. The precipitated crystals were collected by filtration, and were washed with ethanol (9 mL). The wet crystal was dried at room temperature under reduced pressure, to thereby give 2.76 g of the title compound.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwere washed with ethanol (9 mL)
  3. customThe wet crystal was dried at room temperature under reduced pressure

Sources & evidence

ORD record
ord-9b9ce38dc6634dd3bbdafc108f875b26
Source dataset
uspto-grants-2009_06
Patent number
US07547786B2

Reaction notes

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