反应详情

4-(4-Amino-2-fluorophenoxy)picolinamide (0.099 g, 0.40 mmol, Compound C of Example 3) was converted to the desired compound (0.080 g, 44%) in a manner similar to the preparation of 4-(4-(3-(2,4-difluorophenylcarbamoyl)pyridin-4-ylamino)-2-fluorophenoxy)picolinamide (Step D of Example 1), except that N-benzyl-2-chloronicotinamide (Maybridge, 0.099 g, 0.40 mmol) was used instead of 4-chloro-N-(2,4-difluorophenyl)nicotinamide. MS(ESI+) m/z 458 (M+H)+.