HuagongsheHuagongshe Chemistry Print Report · For research reference only
N3-Benzyl-2-chloronicotinamide → 4-(4-(3-(Benzylcarbamoyl)pyridin-2-ylamino)-2-fluorophenoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N3-Benzyl-2-chloronicotinamide | HCID 2794855 | — |
| Reactant | 4-(4-(1h-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt | HCID 16223005 | — |
| Reactant | 2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt | HCID 16223105 | — |
| Product | 4-(4-(3-(Benzylcarbamoyl)pyridin-2-ylamino)-2-fluorophenoxy)picolinamide | HCID 57721341 | 44% |
Reaction Steps
4-(4-Amino-2-fluorophenoxy)picolinamide (0.099 g, 0.40 mmol, Compound C of Example 3) was converted to the desired compound (0.080 g, 44%) in a manner similar to the preparation of 4-(4-(3-(2,4-difluorophenylcarbamoyl)pyridin-4-ylamino)-2-fluorophenoxy)picolinamide (Step D of Example 1), except that N-benzyl-2-chloronicotinamide (Maybridge, 0.099 g, 0.40 mmol) was used instead of 4-chloro-N-(2,4-difluorophenyl)nicotinamide. MS(ESI+) m/z 458 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547782B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-03e0aa2262884e9089a12b42fb70fdcc |
| Source note | uspto-grants-2009_06 |