Water → HCID 57721608, compound

HRID 1986159Notes

Reaction equation

HRID 1986159 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[CH:3]=1.[CH3:24][O:25][CH2:26][CH2:27][NH:28][CH3:29].O>CN(C=O)C>[CH3:24][O:25][CH2:26][CH2:27][N:28]([CH3:29])[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 300977(2-Methoxyethyl)(methyl)amineHCID 57721734HCID 57721734, compound

Product 1

HCID 57721608HCID 57721608, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

Dissolved 4-fluoro-1-nitro-2-[2-(3-trifluoromethylphenyl)ethoxy]benzene (200 mg, 0.61 mmol) in DMF (1 mL) and added N-(2-methoxyethyl)methylamine (270 mg, 3.04 mmol). Reaction Mixture was warmed to 60° C. and stirred for 18 h. The reaction mixture was poured into H2O and extracted with EtOAc (2×). The combined organics were washed with brine and dried over Na2SO4. The title compound was carried on crude to the next step.

Workup

  1. customReaction Mixture
  2. extractionextracted with EtOAc (2×)
  3. washThe combined organics were washed with brine
  4. dry with materialdried over Na2SO4

Sources & evidence

ORD record
ord-53cd3f38e9b24fd8a7f445c7ac18351b
Source dataset
uspto-grants-2009_06
Patent number
US07547804B2

Reaction notes

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