Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate → tert-butyl 5-(2-aminoethyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

HRID 1986163Notes

Reaction equation

HRID 1986163 reaction equation
C(OC([N:8]1CCN(CCCN)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:18]([O:22][C:23]([N:25]1[CH2:32][CH:31]2[CH:27]([CH2:28][NH:29][CH2:30]2)[CH2:26]1)=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23]([N:25]1[CH2:26][CH:27]2[CH:31]([CH2:30][N:29]([CH2:10][CH2:9][NH2:8])[CH2:28]2)[CH2:32]1)=[O:24])([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 4142526Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylateHCID 177509451-tert-Butyloxycarbonyl-4-(3-aminopropyl)piperazine

Product 1

HCID 68857810tert-butyl 5-(2-aminoethyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Procedure

Using the method of 4-(3-aminopropyl)-piperazine-1-carboxylic acid tert-butyl ester, the title compound is synthesized from hexahydropyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-a426c7dbe5994a5aa92b5f4d7361a05f
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

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