反应详情

温度

90 °C

A mixture of 6-bromobenzo[b]thiophene (2.0 g, 9.4 mmol) and sodium thiomethoxide (1.30 g, 18.8 mmol) in DMF (15 mL) is stirred at 90° C. under nitrogen for 6 hours. The reaction is cooled to room temperature, extracted with ethyl acetate and saturated aqueous sodium chloride, washed with 2 N aqueous NaOH solution, saturated aqueous sodium chloride, dried over Na2SO4, filtered, and evaporated. The residue is purified by chromatography on silica gel, eluting with ethyl acetate:hexanes 3:7, to give the title product as a red liquid (1.41 g) which is used for next reaction without further purification.

1. temperatureThe reaction is cooled to room temperature
2. extractionextracted with ethyl acetate and saturated aqueous sodium chloride
3. washwashed with 2 N aqueous NaOH solution, saturated aqueous sodium chloride
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customevaporated
7. customThe residue is purified by chromatography on silica gel
8. washeluting with ethyl acetate:hexanes 3:7