1-N-Boc-4-Piperidinecarboxylic acid methyl ester → 1-Tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate

HRID 1986212Notes

Reaction equation

HRID 1986212 reaction equation
[CH3:1][O:2][C:3]([C:5]1([CH3:18])[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]1)=[O:4].[CH3:19]OC(C1CCN(C(OC(C)(C)C)=O)CC1)=O>>[CH3:1][O:2][C:3]([C:5]1([CH2:18][CH3:19])[CH2:6][CH2:7][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:9][CH2:10]1)=[O:4]

Participants

3

Reactant 2

HCID 3928701-N-Boc-4-Piperidinecarboxylic acid methyl esterHCID 463183881-tert-Butyl 4-methyl 4-methylpiperidine-1,4-dicarboxylate

Product 1

HCID 463183891-Tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate

Procedure

Using the method of 4-methylpiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester, the title compound is synthesized from piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester and isolated as a tan oil.

Workup

  1. customisolated as a tan oil

Sources & evidence

ORD record
ord-11576c155f1442ff8bbe02c54f39acbe
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

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