HCID 86625367, compound → HCID 68856069, compound

HRID 1986235Notes

Reaction equation

HRID 1986235 reaction equation
COC1C=CC(C([NH:18][C:19]([C:21]2[CH:22]=[CH:23][C:24]3[CH:28]=[C:27]([C:29]4[C:34]([Cl:35])=[CH:33][N:32]=[C:31]([NH:36][CH2:37][CH2:38][CH2:39][N:40]5[CH2:45][CH2:44][N:43]([CH3:46])[CH2:42][CH2:41]5)[N:30]=4)[S:26][C:25]=3[CH:47]=2)=[O:20])C2C=CC(OC)=CC=2)=CC=1>Cl.Cl.Cl.ClC1C(C2SC3C=CC=C(C(N)=O)C=3C=2)=NC(NCCCN2CCN(C)CC2)=NC=1>[ClH:35].[ClH:35].[ClH:35].[Cl:35][C:34]1[C:29]([C:27]2[S:26][C:25]3[CH:47]=[C:21]([C:19]([NH2:18])=[O:20])[CH:22]=[CH:23][C:24]=3[CH:28]=2)=[N:30][C:31]([NH:36][CH2:37][CH2:38][CH2:39][N:40]2[CH2:41][CH2:42][N:43]([CH3:46])[CH2:44][CH2:45]2)=[N:32][CH:33]=1

Participants

3

Reactant 1

HCID 86625367HCID 86625367, compound

Product 1

HCID 68856069HCID 68856069, compound

Reagents, catalysts & solvents 1

HCID 68856920HCID 68856920, compoundSolvent

Procedure

Using the method of Preparation C in 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid amide tri-hydrochloride, the title compound is synthesized from 2-{5-chloro-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-6-carboxylic acid [bis-(4-methoxyphenyl)-methyl]-amide and isolated as a yellow solid. ES+(m/z) 445 (35Cl) and 447 (37Cl) [M+H].

Workup

  1. customisolated as a yellow solid

Sources & evidence

ORD record
ord-57e1394e13b44b41ba0aa94a39fe0bcb
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

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