1-tert-Butyloxycarbonyl-4-(3-aminopropyl)piperazine → {2-[5-Chloro-2-(3-piperazin-1-ylpropylamino)-pyrimidin-4-yl]-benzo[b]thiophen-6-yl}-morpholin-4-ylmethanone tri-hydrochloride

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Reaction Steps

Using the method of 2-[5-chloro-2-(3-piperazin-1-ylpropylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride, the title compound is synthesized from [2-(2,5-dichloropyrimidin-4-yl)-benzo[b]thiophen-6-yl]-morpholin-4-yl-methanone and 4-(3-aminopropyl)-piperazine-1-carboxylic acid tert-butyl ester and isolated as a yellow solid. ES+(m/z) 501 (35Cl) and 503 (37Cl) [M+H].

Provenance & Evidence