HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Aminopropyl)-4-methylpiperazine → [5-Bromo-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Aminopropyl)-4-methylpiperazine | HCID 78328 | — |
| Reactant | [4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride | HCID 68855962 | — |
| Reactant | 5-Bromo-2-chloro-4-(7-methoxy-benzo[b]thiophen-2-yl)-pyrimidine | HCID 86625370 | — |
| Product | [5-Bromo-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride | HCID 68856938 | — |
Reaction Steps
Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is prepared from 5-bromo-2-chloro-4-(7-methoxy-benzo[b]thiophen-2-yl)-pyrimidine and 1-(3-aminopropyl)-4-methylpiperazine and isolated as a yellow solid. ES+(m/z) 476 (79Br) and 478 (81Cl) [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547691B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-93cbef253ef146b4938fec8ce1447d5e |
| Source note | uspto-grants-2009_06 |