2-{5-Chloro-2-[3-(2,6-cis-dimethylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide → HCID 68857773, compound

HRID 1986269Notes

Reaction equation

HRID 1986269 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[C:15]3[CH:14]=[C:13]([C:16]4[C:21](Cl)=[CH:20][N:19]=[C:18]([NH:23][CH2:24][CH2:25][CH2:26][N:27]5[C@H:32]([CH3:33])[CH2:31][NH:30][CH2:29][C@@H:28]5[CH3:34])[N:17]=4)[S:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)=[O:6])[CH2:3][CH2:2]1.[CH:35]1(NC(C2C3C=C(C4C(C)=CN=C(Cl)N=4)SC=3C=CC=2)=O)CC1.C(N1C[C@@H](C)N(CCCN)[C@@H](C)C1)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH:1]1([NH:4][C:5]([C:7]2[C:15]3[CH:14]=[C:13]([C:16]4[C:21]([CH3:35])=[CH:20][N:19]=[C:18]([NH:23][CH2:24][CH2:25][CH2:26][N:27]5[CH:32]([CH3:33])[CH2:31][NH:30][CH2:29][CH:28]5[CH3:34])[N:17]=4)[S:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)=[O:6])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 688559882-{5-Chloro-2-[3-(2,6-cis-dimethylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamideHCID 688573483-(4-Benzhydryl-2,6-cis-dimethyl-piperazin-1-yl)-propylamineHCID 866253772-(2-Chloro-5-methylpyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide

Product 1

HCID 68857773HCID 68857773, compound

Procedure

Using the method of 2-{5-chloro-2-[3-(2,6-cis-dimethylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide, the title compound is synthesized from 2-(2-chloro-5-methylpyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 3-(4-benzhydryl-2,6-cis-dimethylpiperazin-1-yl)-propylamine as a yellow solid. ES+(m/z) 479 [M+H].

Sources & evidence

ORD record
ord-1789426a2b1d42528891b316deac3bf2
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

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