HCID 68871620, compound → HCID 68869859, compound

HRID 1986385Notes

Reaction equation

HRID 1986385 reaction equation
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[C:4]([O:11][C:12]2[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:3]=1>CO.[Pd]>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[C:4]([O:11][C:12]2[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:3]=1

Participants

4

Reactant 1

HCID 68871620HCID 68871620, compound

Product 1

HCID 68869859HCID 68869859, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of the product of Step 2 in MeOH (180 mL) and EtOAC (50 mL), was added 10% palladium on carbon (280 mg). This mixture was then stirred under hydrogen atmosphere for 36 h. The reaction mixture was filtered and then concentrated to afford the title compound, which was used directly to next step without further purification. MS (ES+) m/e 260 [M+H]+.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-0b355a0c4ee24d15819667ac5613102d
Source dataset
uspto-grants-2009_06
Patent number
US07547779B2

Reaction notes

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