4-Bromoaniline → (2-Amino-5-bromophenyl)(2,6-difluorophenyl)methanone

Temperature

180 °C

4-Bromoaniline (14.9 g, 86.5 mmol) was heated to 120° C. and 2,6-difluorobenzoyl chloride (36.7 g, 208 mmol) was added. The temperature of the mixture was raised to 180° C. and zinc chloride (14.2 g, 104 mmol) was added. The temperature of the mixture was raised to 205° C. and the mixture was stirred for 3 hrs. The reaction mixture was cooled to 150° C., and 4N hydrochloric acid (100 ml) was added, and the mixture was heated under reflux for 15 min. The supernatant was removed, 4N hydrochloric acid (100 ml) was added to the residue, and the mixture was heated under reflux for 15 min. The supernatant was removed and the residue was dissolved in acetic acid (85 ml). Conc. hydrochloric acid (85 ml) was added at 120° C. and the mixture was heated under reflux for 12 hrs. The reaction mixture was concentrated under reduced pressure and 1N aqueous sodium hydroxide solution (200 ml) was added to the residue. The mixture was extracted with ethyl acetate, and the extract was washed with 1N hydrochloric acid and saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to give a crude product of (2-amino-5-bromophenyl)(2,6-difluorophenyl)methanone (7.8 g). To a solution of the crude product (5.2 g) and 5-methyl-3-oxohexanenitrile (2.1 g, 17 mmol) in toluene (100 ml) was added methanesulfonic acid (1.6 g, 17 mmol) and the mixture was heated under reflux for 17 hrs. The reaction mixture was washed with saturated aqueous sodium hydrogen carbonate and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to give 6-bromo-4-(2,6-difluorophenyl)-2-isobutylquinoline-3-carbonitrile (1.6 g, yield 4.6%) as a yellow solid.

1. temperatureThe temperature of the mixture was raised to 205° C.
2. temperatureThe reaction mixture was cooled to 150° C.
3. temperaturethe mixture was heated
4. temperatureunder reflux for 15 min
5. customThe supernatant was removed
6. addition4N hydrochloric acid (100 ml) was added to the residue
7. temperaturethe mixture was heated
8. temperatureunder reflux for 15 min
9. customThe supernatant was removed
10. dissolutionthe residue was dissolved in acetic acid (85 ml)
11. additionConc. hydrochloric acid (85 ml) was added at 120° C.
12. temperaturethe mixture was heated
13. temperatureunder reflux for 12 hrs
14. concentrationThe reaction mixture was concentrated under reduced pressure and 1N aqueous sodium hydroxide solution (200 ml)
15. additionwas added to the residue
16. extractionThe mixture was extracted with ethyl acetate
17. washthe extract was washed with 1N hydrochloric acid and saturated brine
18. dry with materialdried over anhydrous magnesium sulfate
19. customThe solvent was evaporated under reduced pressure
20. customthe residue was purified by silica gel column chromatography

ORD record

ord-e64637ccca9c4a8bad41a416fa0ef15b

Source dataset

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07547710B2