HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Amino-4-(3,4-difluoro-benzyl)perhydro-1,4-thiazepin-5-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl[4-(3,4-difluoro-benzyl)-5-oxoperhydro-1,4-thiazepin-6-yl]-carbamate | HCID 57722291 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Amino-4-(3,4-difluoro-benzyl)perhydro-1,4-thiazepin-5-one hydrochloride | HCID 69065716 | — |
Reaction Steps
460 mg of 30 (1.235 mmol) are taken up in a 25 ml round-bottomed flask and 9.3 ml of a solution of hydrogen chloride in dioxane (4M) are added. The medium is stirred for 4 hours at room temperature under argon. After evaporating off the solvent, 460 mg of amine 31 are obtained in hydrochloride form, which product is used directly in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550453B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-0df2cad1ba9749399e8d9b28f25a3238 |
| Source note | uspto-grants-2009_06 |