Hydrochloric Acid → 6-Amino-4-(3,4-difluoro-benzyl)perhydro-1,4-thiazepin-5-one hydrochloride

HRID 1986538Notes

Reaction equation

HRID 1986538 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:5][N:6]1[C:12](=[O:13])[CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10][S:9][CH2:8][CH2:7]1.[ClH:26]>O1CCOCC1>[ClH:26].[NH2:14][CH:11]1[CH2:10][S:9][CH2:8][CH2:7][N:6]([CH2:5][C:4]2[CH:22]=[CH:23][C:24]([F:25])=[C:2]([F:1])[CH:3]=2)[C:12]1=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57722291Tert-butyl[4-(3,4-difluoro-benzyl)-5-oxoperhydro-1,4-thiazepin-6-yl]-carbamate

Product 1

HCID 690657166-Amino-4-(3,4-difluoro-benzyl)perhydro-1,4-thiazepin-5-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

460 mg of 30 (1.235 mmol) are taken up in a 25 ml round-bottomed flask and 9.3 ml of a solution of hydrogen chloride in dioxane (4M) are added. The medium is stirred for 4 hours at room temperature under argon. After evaporating off the solvent, 460 mg of amine 31 are obtained in hydrochloride form, which product is used directly in the following step.

Workup

  1. customAfter evaporating off the solvent, 460 mg of amine 31
  2. customare obtained in hydrochloride form, which product

Sources & evidence

ORD record
ord-0df2cad1ba9749399e8d9b28f25a3238
Source dataset
uspto-grants-2009_06
Patent number
US07550453B2

Reaction notes

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