Hydrochloric Acid → 6-Amino-4-(3,5-difluorobenzyl)-perhydro-1,4-thiazepin-5-one hydrochloride

HRID 1986540Notes

Reaction equation

HRID 1986540 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[C:23]([F:25])[CH:24]=1)[CH2:5][N:6]1[C:12](=[O:13])[CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10][S:9][CH2:8][CH2:7]1.[ClH:26]>O1CCOCC1>[ClH:26].[NH2:14][CH:11]1[CH2:10][S:9][CH2:8][CH2:7][N:6]([CH2:5][C:4]2[CH:3]=[C:2]([F:1])[CH:24]=[C:23]([F:25])[CH:22]=2)[C:12]1=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57722274Tert-butyl[4-(3,5-difluoro-benzyl)-5-oxoperhydro-1,4-thiazepin-6-yl]carbamate

Product 1

HCID 690647076-Amino-4-(3,5-difluorobenzyl)-perhydro-1,4-thiazepin-5-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

230 mg of 33 (1.235 mmol) are taken up in a 25 ml round-bottomed flask and 5 ml of a solution of hydrogen chloride in dioxane (4M) are added. The medium is stirred for 2 hours at room temperature under argon. After evaporating off the solvent, 230 mg of amine 34 are obtained in hydrochloride form, which product is used directly in the following step.

Workup

  1. customAfter evaporating off the solvent, 230 mg of amine 34
  2. customare obtained in hydrochloride form, which product

Sources & evidence

ORD record
ord-e71a228d363947e683a35506ce892cc4
Source dataset
uspto-grants-2009_06
Patent number
US07550453B2

Reaction notes

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