HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Amino-4-(2,6-dichloropyrid-4-ylmethyl)perhydro-1,4-thiazepin-5-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl[4-(2,6-dichloropyrid-4-ylmethyl)-5-oxoperhydro-1,4-thiazepin-6-yl]carbamate | HCID 57722295 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Amino-4-(2,6-dichloropyrid-4-ylmethyl)perhydro-1,4-thiazepin-5-one hydrochloride | HCID 86615626 | — |
Reaction Steps
230 mg of 36 (0.57 mmol) are taken up in a 25 ml round-bottomed flask and 3 ml of a solution of hydrogen chloride in dioxane (4M) are added. The mixture is stirred for 2 hours at room temperature under argon. After evaporating off the solvent, 290 mg of amine 37 are obtained in hydrochloride form, which product is used directly in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550453B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-951182d3a72e4618a1391ab9d210e9b8 |
| Source note | uspto-grants-2009_06 |