Hydrochloric Acid → 6-Amino-4-(2,6-dichloropyrid-4-ylmethyl)perhydro-1,4-thiazepin-5-one hydrochloride

HRID 1986542Notes

Reaction equation

HRID 1986542 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][N:9]2[C:15](=[O:16])[CH:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13][S:12][CH2:11][CH2:10]2)[CH:5]=[C:4]([Cl:25])[N:3]=1.Cl>O1CCOCC1>[ClH:1].[NH2:17][CH:14]1[CH2:13][S:12][CH2:11][CH2:10][N:9]([CH2:8][C:6]2[CH:5]=[C:4]([Cl:25])[N:3]=[C:2]([Cl:1])[CH:7]=2)[C:15]1=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57722295Tert-butyl[4-(2,6-dichloropyrid-4-ylmethyl)-5-oxoperhydro-1,4-thiazepin-6-yl]carbamate

Product 1

HCID 866156266-Amino-4-(2,6-dichloropyrid-4-ylmethyl)perhydro-1,4-thiazepin-5-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

230 mg of 36 (0.57 mmol) are taken up in a 25 ml round-bottomed flask and 3 ml of a solution of hydrogen chloride in dioxane (4M) are added. The mixture is stirred for 2 hours at room temperature under argon. After evaporating off the solvent, 290 mg of amine 37 are obtained in hydrochloride form, which product is used directly in the following step.

Workup

  1. customAfter evaporating off the solvent, 290 mg of amine 37
  2. customare obtained in hydrochloride form, which product

Sources & evidence

ORD record
ord-951182d3a72e4618a1391ab9d210e9b8
Source dataset
uspto-grants-2009_06
Patent number
US07550453B2

Reaction notes

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