HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Amino-4-(4-butoxybenzyl)-perhydro-1,4-thiazepin-5-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl[4-(4-butoxybenzyl)-5-oxoperhydro-1,4-thiazepin-6-yl]carbamate | HCID 57722320 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Amino-4-(4-butoxybenzyl)-perhydro-1,4-thiazepin-5-one hydrochloride | HCID 69065608 | — |
Reaction Steps
260 mg of 39 (0.64 mmol) are taken up in a 25 ml round-bottomed flask and 4 ml of a solution of hydrogen chloride in dioxane (4M) are added. The mixture is stirred for 4 hours at room temperature under argon. After evaporating off the solvent, 280 mg of amine 40 are obtained in hydrochloride form, which product is used directly in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550453B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-b21a6f6696b048b5831559b9c5da9918 |
| Source note | uspto-grants-2009_06 |