Hydrochloric Acid → 6-Amino-4-(4-butoxybenzyl)-perhydro-1,4-thiazepin-5-one hydrochloride

HRID 1986544Notes

Reaction equation

HRID 1986544 reaction equation
[CH2:1]([O:5][C:6]1[CH:28]=[CH:27][C:9]([CH2:10][N:11]2[C:17](=[O:18])[CH:16]([NH:19]C(=O)OC(C)(C)C)[CH2:15][S:14][CH2:13][CH2:12]2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].[ClH:29]>O1CCOCC1>[ClH:29].[NH2:19][CH:16]1[CH2:15][S:14][CH2:13][CH2:12][N:11]([CH2:10][C:9]2[CH:27]=[CH:28][C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[CH:7][CH:8]=2)[C:17]1=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57722320Tert-butyl[4-(4-butoxybenzyl)-5-oxoperhydro-1,4-thiazepin-6-yl]carbamate

Product 1

HCID 690656086-Amino-4-(4-butoxybenzyl)-perhydro-1,4-thiazepin-5-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

260 mg of 39 (0.64 mmol) are taken up in a 25 ml round-bottomed flask and 4 ml of a solution of hydrogen chloride in dioxane (4M) are added. The mixture is stirred for 4 hours at room temperature under argon. After evaporating off the solvent, 280 mg of amine 40 are obtained in hydrochloride form, which product is used directly in the following step.

Workup

  1. customAfter evaporating off the solvent, 280 mg of amine 40
  2. customare obtained in hydrochloride form, which product

Sources & evidence

ORD record
ord-b21a6f6696b048b5831559b9c5da9918
Source dataset
uspto-grants-2009_06
Patent number
US07550453B2

Reaction notes

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