HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Amino-4-(naphthalen-2-yl-methyl)perhydro-1,4-thiazepin-5-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl [4-(naphthalen-2-ylmethyl)-5-oxoperhydro-1,4-thiazepin-6-yl]carbamate | HCID 57722245 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Amino-4-(naphthalen-2-yl-methyl)perhydro-1,4-thiazepin-5-one hydrochloride | HCID 69065783 | — |
Reaction Steps
510 mg of 42 (1.32 mmol) are taken up in a 25 ml round-bottomed flask and 10 ml of a solution of hydrogen chloride in dioxane (4M) are added. The mixture is stirred for 3 hours at room temperature under argon. After evaporating off the solvent, 510 mg of amine 43 are obtained in hydrochloride form, which product is used directly in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550453B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-3c5eab112b034310aa41473302e4cd6b |
| Source note | uspto-grants-2009_06 |